Advancement of E2F1 in Common Tumors.
10.3779/j.issn.1009-3419.2020.101.32
- Author:
Cheng SHEN
1
;
Jue LI
1
;
Shuai CHANG
1
;
Guowei CHE
1
Author Information
1. Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
- Publication Type:Journal Article
- Keywords:
Cell cycle-related transcription factor;
E2F1;
Tumor
- From:
Chinese Journal of Lung Cancer
2020;23(10):921-926
- CountryChina
- Language:Chinese
-
Abstract:
The cell cycle-related transcription factor E2F1 is a member of the cell cycle-related transcription factor E2F family, mainly involved in various cell processes including cell cycle progression, DNA repair, DNA replication, cell differentiation, proliferation, and apoptosis. E2F1 is highly expressed in a variety of tumor tissues and cells, and it plays a role as a cancer-promoting gene. The up-regulation of E2F1 expression is closely related to the occurrence, development, metastasis and prognosis of tumors. Therefore, E2F1 is expected to become a new target for cancer treatment. This article reviews the latest research progress of E2F1 in current common tumors.
.
