A Literature Review on the Role of TBX5 in Expression and Progression of Lung Cancer: Current Perspectives.
10.3779/j.issn.1009-3419.2020.102.27
- Author:
Weijia HUANG
1
;
Peiwei LI
1
;
Xiaoming QIU
2
Author Information
1. West China School of Medicine, Sichuan University, Chengdu 610041, China.
2. Department of Lung Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China.
- Publication Type:Journal Article
- Keywords:
DNA methylation;
Disease progression;
Gene expression;
Lung neoplasms;
T-box transcription factor gene
- From:
Chinese Journal of Lung Cancer
2020;23(10):883-888
- CountryChina
- Language:Chinese
-
Abstract:
T-box transcription factor gene (TBX) interferes with the origin and development of organs, and TBX5 is expressed highest in normal cardiac and pulmonary tissues. Lack of TBX5 may lead to thoracic malformation and abnormal diaphragmatic development, in which ectopic expression and overexpression may induce the apoptosis of cell and inhibit the development of cell. Previous studies demonstrated the potential role of TBX5 in the development and progression of esophageal adenocarcinoma, gastric cancer, colon cancer and breast cancer. We reviewed the association between the expression of TBX2 subfamily and the prognosis, and explore the research progress of TBX5 in regulating the development and progression of lung cancer. Even though the relationshihp the development of lung cancer and TBX5 are not clear, TBX5 could significantly inhibit in vivo tumor growth, and the level of TBX5 was negatively correlated with lung cancer progression. Therefore, the gene expression levels and methylation extent of TBX could be a potential biomarker to reveal the proliferation and metastasis of lung cancer, as well as a therapeutic target for lung cancer.
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