Kinetics of Infiltrating CD3
10.19746/j.cnki.issn.1009-2137.2021.03.044
- Author:
Kai ZHAO
1
;
Su-Hong RUAN
2
;
Yu TIAN
1
;
Kai-Lin XU
3
,
4
Author Information
1. Blood Diseases Institute, Xuzhou Medical University, Department of Hematology of The Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, Jiangsu Province, China.
2. Blood Diseases Institute, Xuzhou Medical University, Department of Hematology of The Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, Jiangsu Province, China,Department of Hematology, Suzhou Municipal Hospital, Suzhou 215002, Jiangsu Province, China.
3. Blood Diseases Institute, Xuzhou Medical University, Department of Hematology of The Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, Jiangsu Province, China,E-mail: lihmd@
4. com.
- Publication Type:Journal Article
- MeSH:
Animals;
Bone Marrow Transplantation;
Graft vs Host Disease;
Kinetics;
Male;
Mice;
Mice, Inbred BALB C;
Mice, Inbred C57BL;
T-Lymphocytes;
Transplantation, Homologous
- From:
Journal of Experimental Hematology
2021;29(3):931-936
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the kinetics of infiltrated T cell in murine acute graft-versus-host disease (aGVHD) target organs after allogeneic hematopoietic stem cell transplantation (allo-HSCT) and its relationship with tissue pathological damage and aGVHD progress.
METHODS:Male C57BL/6 (H-2K
RESULTS:Compared with BMT group, the number of infiltrated T cells in aGVHD target organs including liver, lung and gut increased since day 7 in BMT+T group (P<0.05). On day 14, 28, 40 and 47 after transplantation, more infiltrated CD3
CONCLUSION:Pathological damage of aGVHD target organs is induced by CD3
