Value of Neutrophil/Lymphocyte Ratio and Monocyte/Lymphocyte Ratio in the Prognosis of Patients with Multiple Myeloma.
10.19746/j.cnki.issn.1009-2137.2021.01.020
- Author:
Wen-Hui YANG
1
;
Yan-Qing SUN
2
;
Qi-Ke ZHANG
3
;
Xiao-Fang WEI
3
;
Gao LI
3
Author Information
1. Gansu Provincial Hospital of TCM, Lanzhou 730000, Gansu Province, China,Ningxia Medical University, Yinchuan 750000, Ningxia Province, China.
2. Department of Hematology, Gansu Provincial People's Hospital, Lanzhou 730000, Gansu Province, China,E-mail: 491049515@qq.com.
3. Department of Hematology, Gansu Provincial People's Hospital, Lanzhou 730000, Gansu Province, China.
- Publication Type:Journal Article
- MeSH:
Blood Platelets;
Humans;
Lymphocytes;
Monocytes;
Multiple Myeloma;
Neutrophils;
Prognosis;
Retrospective Studies
- From:
Journal of Experimental Hematology
2021;29(1):122-130
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the effect of neutrophil/lymphocyte ratio (NLR) and monocyte/lymphocyte ratio (MLR) in the valuation prognosis of patients with multiple myeloma (MM).
METHODS:The clinical data of 82 patients with initially diagnosed MM admitted to Gansu Provincial People's Hospital was analyzed retrospectively. NLR and MLR were calculated based on blood routine results respectively. The optimal cut-off point of NLR and MLR was determined according to the ROC curve, and the patients were divided into the high NLR/MLR group and the low NLR/MLR group. The general data, biochemical indicators and prognosis of the patients in each groups were compared respectively. The prognostic significance of the high NLR/MLR group and the low NLR/MLR group in patients between different treatment regimens and different clinical characteristics were analyzed. Risk stratification was designed based on NLR and high MLR as two risk factors, and the effect of risk factors, on the prognosis of MM patients were compared.
RESULTS:ROC curve analysis determined that the optimal cut-off point of NLR was 3.1 (sensitivity 75%, specificity 70.7%) and the optimal cut-off point of MLR was 0.34 (sensitivity 83.3%, specificity 53.4%). The lactate dehydrogenase (LDH) and mean platelet volume (MPV) were correlated to NLR and MLR (P<0.05). There were no significant difference in age, sex, serum calcium (Ca), β
CONCLUSION:Elevated NLR and MLR are associated with poor prognosis in MM patients and may serve as the cost-effective and readily available prognostic biomarkers.
