Value of SQLE Expression in Prognostic Evaluation of Patients with Acute Myeloid Leukemia.
10.19746/j.cnki.issn.1009-2137.2021.01.002
- Author:
Yan-Qing MA
1
;
Yu-Chen LIU
1
;
Cheng-Liang YIN
2
;
Li-Li WANG
1
;
Dai-Hong LIU
1
;
Jin-Long SHI
3
;
Li-Ping DOU
4
,
5
Author Information
1. Department of Hematology, First Medical Center of the Chinese PLA General Hospital, Beijing 100853, China.
2. Department of Medical Big Data, First Medical Center of the Chinese PLA General Hospital, Beijing 100853, China.
3. Department of Medical Big Data, First Medical Center of the Chinese PLA General Hospital, Beijing 100853, China E-mail:shijinlong@301hospital.com.cn.
4. Department of Hematology, First Medical Center of the Chinese PLA General Hospital, Beijing 100853, China E-mail: lipingruirui@
5. com.
- Publication Type:Journal Article
- MeSH:
Disease-Free Survival;
Humans;
Leukemia, Myeloid, Acute;
Prognosis;
Survival Rate;
Transcriptome
- From:
Journal of Experimental Hematology
2021;29(1):9-16
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To analyze the relationship between the expression level of SQLE and the prognosis of patients with acute myeloid leukemia (AML) through large sample data.
METHODS:The data of genome, transcriptome, gene chip expression, and clinical information were statistically analyzed in multiple cohorts of AML patients with large samples.
RESULTS:It was found that the expression level of SQLE gene in tumor cells of AML patients was significantly higher than that of healthy controls (P=0.001). In the three AML corhort, the SQLE high expression group showed a worse therapeutic outcome (OS, P=0.009, P=0.0001, P=0.006; EFS, P=0.005, P=0.001). The unvariate and multivariate survival prognosis analysis indicated that the high expression of SQLE suggests lower event-free survival rate (EFS, HR=1.551, P<0.05) and overall survival rate (OS, HR=1.484, P<0.05). At the same time, it was also found that among different risk subgroups, the expression of SQLE in high risk group was higher (P<0.001, P=0.01), while the patients with high SQLE expression, who received allogeneic HSCT, had longer overall survival time (P=0.006).
CONCLUSION:The up-regulation SQLE expression suggests a poor prognosis for the patients with AML.
