Clinical features and prognosis of childhood acute myeloid leukemia with myelodysplasia-related changes.

Ting-Ting HAN; Xiao-Wen GONG; Ran-Ran ZHANG; Min RUAN; Ye GUO; Li ZHANG; Yao ZOU; Yu-Mei CHEN; Xiao-Fan ZHU; Wen-Yu YANG

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Clinical features and prognosis of childhood acute myeloid leukemia with myelodysplasia-related changes.

Author: Ting-Ting HAN ¹ ; Xiao-Wen GONG ¹ ; Ran-Ran ZHANG ¹ ; Min RUAN ¹ ; Ye GUO ¹ ; Li ZHANG ¹ ; Yao ZOU ¹ ; Yu-Mei CHEN ¹ ; Xiao-Fan ZHU ¹ ; Wen-Yu YANG ¹
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1. Institute of Hematology&Blood Disease Hospital, Chinese Academy of Medical Sciences&Peking Union Medical College/State Key Laboratory of Experimental Hematology/National Clinical Research Center for Blood Diseases, Tianjin 300020, China.
Publication Type:Journal Article
MeSH: Adolescent; Child; Child, Preschool; Female; Hematopoietic Stem Cell Transplantation; Humans; Infant; Leukemia, Myeloid, Acute/therapy*; Male; Myelodysplastic Syndromes/therapy*; Prognosis; Retrospective Studies
From: Chinese Journal of Contemporary Pediatrics 2021;23(3):271-278
CountryChina
Language:Chinese
Abstract: OBJECTIVE:To study the clinical features and prognosis of childhood acute myeloid leukemia with myelodysplasia-related changes (AML-MRC).
METHODS:A retrospective analysis was performed on the medical data of 14 children who were diagnosed with AML-MRC from June 2014 to March 2020, including clinical features, laboratory examination results, and prognosis.
RESULTS:Among the 14 children with AML-MRC, there were 9 boys and 5 girls, with a median age of 11 years (range: 1-17 years), a median leukocyte count of 8.3×10
CONCLUSIONS:Childhood AML-MRC is often observed in boys, and AML-M5 is the most common type based on FAB classification. Such children tend to have a poor prognosis. HSCT is expected to improve the poor prognosis of children with AML-MRC. However due to the small number of cases, it is necessary to increase the number of cases for further observation.