Clinicopathological features of children with lupus nephritis with positive antineutrophil cytoplasmic antibody.
- Author:
Si-Jia WEN
1
;
Li-Zhi CHEN
1
;
Cheng CHENG
1
;
Zhi-Lang LIN
1
;
Ying MO
1
;
Xiao-Yun JIANG
1
Author Information
1. Children Kidney Disease Center, First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China.
- Publication Type:Journal Article
- MeSH:
Antibodies, Antineutrophil Cytoplasmic;
Child;
Creatinine;
Humans;
Kidney;
Lupus Nephritis;
Retrospective Studies
- From:
Chinese Journal of Contemporary Pediatrics
2021;23(1):55-60
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the clinicopathological features of children with lupus nephritis (LN) with positive anti-neutrophil cytoplasmic antibody (ANCA).
METHODS:A retrospective analysis was performed for the children who were diagnosed with LN in the First Affiliated Hospital of Sun Yat-sen University from January 2003 to December 2019. According to the results of serum ANCA, they were divided into two groups: ANCA-positive group (
RESULTS:Compared with the ANCA-negative group, the ANCA-positive group had a significant reduction in leukocytes and a significant increase in erythrocyte sedimentation rate (
CONCLUSIONS:Children with ANCA-positive LN tend to have more severe renal pathological injury, which is not exactly parallel with clinical manifestations, suggesting that timely renal biopsy is of great importance.
