Association of non-thyroidal illness syndrome with interleukin-6 and interleukin-10 in critically ill children with sepsis.
- Author:
Mei-Xian XU
1
,
2
;
Gang LIU
;
Li-Jing CAO
;
Xin-Feng BAI
;
Lei KANG
;
Xin ZHAO
;
Xiao-Na SHI
;
Li-Jing LI
Author Information
1. Pediatric Intensive Care Unit, Hebei Children's Hospital, Shijiazhuang 050000, China. xumeixian2019@
2. com.
- Publication Type:Journal Article
- MeSH:
Child;
Critical Illness;
Euthyroid Sick Syndromes;
Humans;
Interleukin-10/blood*;
Interleukin-6/blood*;
Retrospective Studies;
Sepsis;
Thyrotropin;
Thyroxine
- From:
Chinese Journal of Contemporary Pediatrics
2020;22(11):1215-1220
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the incidence rate of non-thyroidal illness syndrome (NTIS) in critically ill children with or without sepsis and the association of NTIS with interleukin-6 (IL-6) and interleukin-10 (IL-10).
METHODS:A retrospective analysis was performed on the medical data of 97 children with sepsis (sepsis group) and 80 non-sepsis children with bacterial infection (non-sepsis group). The correlations of IL-6 and IL-10 with the thyroid function parameters triiodothyronine (T3), thyroxine (T4), and thyroid stimulating hormone (TSH) were analyzed.
RESULTS:There were no significant differences in age and sex between the sepsis and non-sepsis groups (P>0.05). Compared with the non-sepsis group, the sepsis group had a significantly higher Sequential Organ Failure Assessment score, a significantly longer length of hospital stay, and a significantly higher rate of use of ventilator (P<0.05). As for inflammation markers, the sepsis group had significantly higher levels of C-reactive protein, procalcitonin, and IL-6 than the non-sepsis group (P<0.05). As for thyroid function parameters, the sepsis group had significantly lower levels of T3, T4, free T3, free T4, and TSH than the non-sepsis group (P<0.05). Compared with the non-sepsis group, the sepsis group had significantly higher incidence rates of NTIS, low T3 and T4, and low TSH (P<0.001). The correlation analysis revealed that IL-6 level was not correlated with T3, T4, and TSH levels in children with or without sepsis (P>0.05), but the pooled analysis of the two groups showed that IL-6 level was negatively correlated with T3 and T4 levels (P<0.001).
CONCLUSIONS:Children with sepsis have a higher incidence rate of NTIS than those without sepsis. The high level of IL-6 may be associated with the development of NTIS.
