Systemic reactions to subcutaneous immunotherapy for bronchial asthma and/or allergic rhinitis in children and their risk factors.
- Author:
Wang LIAO
1
,
2
;
Liang CHEN
;
Jun BAI
Author Information
1. Department of Pediatrics, Foshan Women and Children's Hospital Affiliated to Southern Medical University, Foshan, Guangdong 528000, China. junjun2125@
2. com.
- Publication Type:Journal Article
- MeSH:
Allergens;
Animals;
Asthma/drug therapy*;
Child;
Desensitization, Immunologic;
Humans;
Injections, Subcutaneous;
Retrospective Studies;
Rhinitis, Allergic/therapy*;
Risk Factors
- From:
Chinese Journal of Contemporary Pediatrics
2020;22(11):1204-1208
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the incidence of systemic reactions (SR) to subcutaneous immunotherapy (SCIT) for bronchial asthma and/or allergic rhinitis in children and their risk factors.
METHODS:A retrospective analysis was performed on 198 children with bronchial and/or allergic rhinitis. According to the presence or absence of SR and local reactions (LR) during SCIT, the patients were divided into two groups: SR (with SR and LR, n=31) and control (without SR or LR, n=142). A multivariate logistic regression analysis was used to determine the risk factors associated with SR.
RESULTS:Among the 198 patients who received 8 157 injections of SCIT, 25 (12.6%) experienced SR (31 times, 0.38%), including grade I SR (18 times, 58%), grade II SR (10 times, 32%), grade III SR (3 times, 10%), and no grade IV SR. The multivariate logistic regression analysis showed that multiple sensitization with both food and inhaled allergens, specific IgE to dust mites (grade 6), total IgE (grade 6), and a history of LR were independent risk factors for SR (P<0.05).
CONCLUSIONS:SCIT is a safe treatment for bronchial asthma and/or allergic rhinitis in children, with a low incidence of SR. Children with multiple sensitization with both food and inhaled allergens, a hypersensitive state (specific IgE to dust mites, grade 6; total IgE, grade 6), and a history of LR have an increased risk of SR to SCIT.
