Metformin treatment of high-fat diet-fed obese male mice restores sperm function and fetal growth, without requiring weight loss.
- Author:
Nicole O MCPHERSON
1
;
Michelle LANE
1
Author Information
- Publication Type:Journal Article
- Keywords: fertility; glucose; metabolic syndrome; overweight; subfertility
- From: Asian Journal of Andrology 2020;22(6):560-568
- CountryChina
- Language:English
- Abstract: Male obesity is associated with subfertility and increased disease risk of offspring. It is unknown if effects can be reversed through pharmacological interventions. Five- to 6-week-old C57BL6 male mice were fed control diet (n = 10, CD) or high-fat diet (n = 20, HFD) for 16 weeks. Animals fed with a HFD were then allocated to continuation of HFD (n = 8) or HFD with metformin 28 mg kg
