Inhibition of indoxyl sulfate-induced intrarenal renin-angiotensin system activation: targeting the aryl hydrocarbon receptor.
10.12793/tcp.2017.25.3.114
- Author:
Muhammad Firman AKBAR
1
Author Information
1. Department of General Health Service, Sahabat Sehat Clinic, West Nusa Tenggara, Indonesia, Department of Medicine, University of Melbourne St. Vincent's Hospital Melbourne, Australia. mfakbar@connect.hku.hk
- Publication Type:Brief Communication
- Keywords:
Chronic Kidney Disease;
Indoxyl Sulfate;
Aryl Hydrocarbon Receptor;
Renin-Angiotensin System
- MeSH:
Indican;
Kidney;
Receptors, Aryl Hydrocarbon*;
Renal Insufficiency, Chronic;
Renin-Angiotensin System*
- From:Translational and Clinical Pharmacology
2017;25(3):114-116
- CountryRepublic of Korea
- Language:English
-
Abstract:
Indoxyl sulfate, a protein-bound uremic toxin, leads to CKD (chronic kidney disease) progression and its complications through the activation of AhR (aryl hydrocarbon receptor) and RAS (renin-angiotensin system). Inhibition of these pathways may slow the development of CKD and CKD-associated complications.
