Inhibition of Murine Allergic Response by Monoclonal Interleukin-4 Receptor Antibody.
- Author:
Chul Hee LEE
1
;
Ja Bock YUN
;
Chae Seo RHEE
;
Seok Won PARK
;
Jeong Whun KIM
Author Information
1. Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University College of Medicine, Seoul, Korea. chulhee@snu.ac.kr
- Publication Type:Original Article
- Keywords:
Interleukin-4 receptor antibody;
Allergic rhinitis;
Treatment
- MeSH:
Animals;
Eosinophils;
Humans;
Immunoglobulin E;
Injections, Intraperitoneal;
Interleukin-4*;
Male;
Mice;
Models, Animal;
Nasal Mucosa;
Nebulizers and Vaporizers;
Ovalbumin;
Ovum;
Rhinitis;
Ultrasonics
- From:Journal of Rhinology
2000;7(2):149-153
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND AND OBJECTIVES: Several strategies were used to control the IgE production by interfering the functional activities of IL-4. However, most of them revealed limited effects to reduction of allergic response. This study was aimed to investigate the effects of interleukin-4 receptor (IL-4R) antibody on allergic response in animal model of allergic rhinitis. MATERIALS AND METHODS: Male BALB/C mice were sensitized with intraperitoneal injection of ovalbumin (OVA). IL-4R antibody was injected intravenously before intranasal challenge of OVA with ultrasonic nebulizer. Allergic symptoms, a number of eosinophils in nasal mucosa and serum level of OVA-specific IgE were evaluated. RESULTS: In IL-4R antibody treated mice, allergic symptom score were decreased (53.5%) than in control mice. The number of eosinophils in nasal mucosa were also reduced (47.4%). However, serum level of OVA-specific IgE were not obviously reduced (14.3%). CONCLUSION: These results suggested that IL-4R antibody has a potential effect for the treatment of allergic rhinitis in vivo.
