Identification of active components of Dendrobium inhibit growth of gastric cancer cells based on component-activity relationship.
10.19540/j.cnki.cjcmm.20201111.202
- Author:
Jia-Ni LIU
1
;
Feng-Zhong WANG
1
;
Jia-Meng LIU
1
;
Ning JIA
1
;
Yu-Feng SUN
1
;
Hui WANG
1
;
Jing SUN
1
;
Bei FAN
1
Author Information
1. Key Laboratory of Agro-Products Quality and Safety in Harvest, Storage, Transportation, Management and Control, Ministry of Agriculture and Rual Affairs, Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences Beijing 100193, China.
- Publication Type:Journal Article
- Keywords:
Dendrobium;
component-activity relationship;
gastric cancer;
grey relation relationship;
partial least squares
- MeSH:
Dendrobium;
Humans;
Least-Squares Analysis;
Multivariate Analysis;
Stomach Neoplasms/drug therapy*
- From:
China Journal of Chinese Materia Medica
2021;46(10):2565-2570
- CountryChina
- Language:Chinese
-
Abstract:
Three cancer cell lines including gastric cancer SGC-7901, HGC-27, and MGC-803 cells were employed to evaluate the bioactivity of seven Dendrobium species. Simultaneously, these Dendrobium species were assessed with UPLC-Q-TOF-MS, and 504 common peaks were found. Based on the hypothesis that biological effects varied with differences in components, multivariate relevance analysis for chemical component-activity relationship of Dendrobium, including grey relation(GRA) and partial least squares(PLS) analysis were performed to evaluate the contribution of each identified component. The target peaks were identified by standards toge-ther with databases of Dendrobium, Nature Chemistry, MassBank, etc. Finally, four active components, including 3,5,9-trihydroxy-23-methylergosta-7,22-dien-6-one, diacylglycerol(14∶1/22∶6/0∶0), pipercitine, and 22-tricosenoic acid, might have negative effect on the growth of gastric cancer cells.
