Analysis of animal models of chronic skin ulcers based on characteristics of clinical symptoms of traditional Chinese and Western medicine.
10.19540/j.cnki.cjcmm.20200918.601
- Author:
Rui WU
1
;
Xiu-Min LI
1
;
Ming-San MIAO
1
Author Information
1. Henan University of Chinese Medicine Zhengzhou 450046,China.
- Publication Type:Journal Article
- Keywords:
animal model;
chronic skin ulcer;
combination of disease
- MeSH:
Animals;
China;
Drugs, Chinese Herbal;
Medicine;
Medicine, Chinese Traditional;
Skin Ulcer/drug therapy*;
Syndrome
- From:
China Journal of Chinese Materia Medica
2021;46(4):782-785
- CountryChina
- Language:Chinese
-
Abstract:
Based on the characteristics of clinical symptoms of chronic skin ulcers in traditional Chinese and Western medicine, the current animal models of skin ulcers are summarized. This article analyzes the advantages and disadvantages of animal models according to the etiology and pathogenesis of chronic skin ulcers, traditional Chinese and Western medicine diagnostic criteria and observation indicators, and eva-luates the agreement between the existing animal models and the characteristics of clinical syndromes of traditional Chinese and Western medicine for chronic skin ulcers. Through analysis and comparison, it is found that most of the existing modeling methods are single-factor animal models, and there are certain gaps in the physiological and pathological characteristics of chronic skin ulcers caused by clinical multi-factors and interactions. Most of the modeling methods are guided by Western medicine. The lack of pathogenic factors of traditional Chinese medicine(TCM) in the process of modeling. Therefore, this article proposes to establish a reasonable quantification standard for chronic skin ulcer animal models, and to establish a combination model of chronic skin ulcer disease with traditional Chinese and Western medicine as the focus of future animal model research.
