Melanin synthesis and regulation in vivo and commonly used melanin inhibitors from natural products and traditional Chinese medicine.
10.19540/j.cnki.cjcmm.20200818.601
- Author:
Zi-Yu MA
1
;
Yang LU
1
Author Information
1. School of Chinese Materia Medica, Beijing University of Chinese Medicine Beijing 102488, China.
- Publication Type:Journal Article
- Keywords:
melanin inhibitor;
melanin synthesis;
melanosome;
tyrosinase;
tyrosinase inhibitor
- MeSH:
Biological Products;
Enzyme Inhibitors;
Humans;
Medicine, Chinese Traditional;
Melanins;
Monophenol Monooxygenase
- From:
China Journal of Chinese Materia Medica
2020;45(24):5898-5916
- CountryChina
- Language:Chinese
-
Abstract:
Melanin is an important factor affecting human skin color. This study defines its synthetic pathways and regulatory pathways have the practical significance for the treatment of diseases caused by pigmentation problems, such as chloasma. Besides, it also provides a theoretical basis for screening out melanin inhibitors and developing whitening and freckle products. At present, the melanin inhibitors used in whitening and freckle products mainly come from natural products and traditional Chinese medicine. This article first introduces the melanin biosynthesis pathway with tyrosinase as the core, defines the synthesis, transport and catalytic activity of tyrosinase as the three key factors affecting melanin synthesis, and then reviews two common types of melanin inhibitors, namely tyrosinase synthesis inhibitors and tyrosinase inhibitors derived from natural products and traditional Chinese medicine. This article provides guidance for the development of new melanin inhibitors, and puts forward the idea for combining and synergizing inhibitors according to different mechanisms, in order to develop new whitening formulas.
