Expression and Prognostic Value of Cripto-1 in Pancreatic Cancer.
10.3881/j.issn.1000-503X.12734
- Author:
Xiang GAO
1
;
Qiang XU
1
;
Rong Hua ZHANG
1
;
Tao LU
2
;
Bo Ju PAN
2
;
Quan LIAO
1
Author Information
1. Department of General Surgery,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
2. Department of Pathology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
- Publication Type:Journal Article
- Keywords:
Cripto-1;
immunohistochemistry;
pancreatic cancer;
prognosis
- MeSH:
Biomarkers, Tumor;
Carcinoma, Pancreatic Ductal;
GPI-Linked Proteins;
Humans;
Intercellular Signaling Peptides and Proteins;
Neoplasm Proteins/genetics*;
Pancreatic Neoplasms;
Prognosis
- From:
Acta Academiae Medicinae Sinicae
2021;43(2):173-179
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of Cripto-1 in pancreatic cancer and to analyze its clinical significance. Methods Cripto-1 expression in normal pancreas,pancreatic cancer and adjacent non-tumor tissues,chronic pancreatitis tissues and other related tissues was evaluated using immunohistochemistry.The association of Cripto-1 expression with the clinicopathological characteristics and the prognostic value of Cripto-1 in patients with pancreatic cancer were analyzed. Results The expression of Cripto-1 was higher in chronic pancreatitis tissues,pancreatic cancer and its metastases than in normal pancreas(P=0.019,P=0.025,and P=0.018,respectively).Cripto-1 overexpression was correlated with poorly differentiated pancreatic cancer.The patients with Cripto-1 upregulation had shorter median survival time(8 months vs.16 months,χ
