Prostate organoid technology - the new POT of gold in prostate stem cell and cancer research.
- Author:
Chun-Wai MAI
1
;
Yu SHU
1
;
Soon-Keng CHEONG
2
;
Chee Wai CHUA
3
Author Information
1. State Key Laboratory of Oncogenes and Related Genes, Ren Ji-Med X Clinical Stem Cell Research Center, Department of Urology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China.
2. Centre for Stem Cell Research, Faculty of Medicine and Health Sciences, Universiti Tunku Abdul Rahman, Selangor 43000, Malaysia.
3. State Key Laboratory of Oncogenes and Related Genes, Ren Ji-Med X Clinical Stem Cell Research Center, Department of Urology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China. cheewaichua@yahoo.com.
- Publication Type:Review
- MeSH:
Gold;
Humans;
Male;
Neoplasms;
Organoids;
Prostate;
Stem Cells;
Technology
- From:
Acta Physiologica Sinica
2021;73(2):181-196
- CountryChina
- Language:English
-
Abstract:
Organoids are self-organized cellular clusters in three-dimensional culture, which can be derived from a single stem cell, progenitor or cell clusters of different lineages resembling in vivo tissue architecture of an organ. In the recent years, organoids technology has contributed to the revolutionary changes in stem cell and cancer fields. In this review, we have briefly overviewed the emerging landscape of prostate organoid technology (POT) in prostate research. In addition, we have also summarized the potential application of POT in the understanding of prostate stem cell and cancer biology and the discovery of novel therapeutic strategies for prostate cancer. Lastly, we have critically discussed key challenges that lie in the current state of POT and provided a future perspective on the second-generation of POT, which should better recapitulate cellular behaviors and drug responses of prostate cancer patients.
