Mechanism of ferroptosis and its role in liver diseases
10.3969/j.issn.1001-5256.2021.06.049
- VernacularTitle:铁死亡的发生机制及在肝脏疾病中的作用
- Author:
Feiyu ZHANG
1
;
Yakepu ADILA
;
Jinming ZHAO
;
Yanhang GAO
Author Information
1. Department of Hepatology, The First Hospital of Jilin University, Changchun 130021, China
- Publication Type:Research Article
- Keywords:
Liver Diseases； Ferroptosis;
Cell Death;
Iron Metabolism
- From:
Journal of Clinical Hepatology
2021;37(6):1454-1458
- CountryChina
- Language:Chinese
-
Abstract:
Ferroptosis is a newly discovered regulatory cell death induced by the accumulation of iron-dependent lipid peroxides, with the morphological manifestations of decreased mitochondrial volume, increased mitochondrial membrane density, and reduction or disappearance of mitochondria. The mechanism of ferroptosis is mainly associated with disturbance of iron metabolism, imbalance of amino acid antioxidant system, and accumulation of lipid peroxides. Studies have shown that ferroptosis plays different roles in different liver diseases, and ferroptosis can participate in the progression of various liver inflammatory diseases and inhibit the formation of liver fibrosis, the development of hepatocellular carcinoma, and sorafenib resistance. This article summarizes the advances in the mechanism of ferroptosis and its role in liver diseases, so as to provide a reference for further research and treatment of liver diseases.
