Meta-analysis of Therapeutic Efficacy and Safety of Nicodil Combined with Atorvastatin Calcium in the Treatment of Unstable Angina Pectoris
- VernacularTitle:尼可地尔联合阿托伐他汀钙治疗不稳定型心绞痛疗效与安全性的Meta分析
- Author:
Liping LI
1
;
Dandan CHEN
2
;
Yunqiang CHEN
3
;
Jiemiao OUYANG
1
Author Information
1. Emergency Department，Haikou Emergency Medical Center，Haikou 570311，China
2. Dept. of Critical Medicine，Haikou People’s Hospital，Haikou 570208，China
3. Emergency Department，Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science & Technology，Wuhan 430030，China
- Publication Type:Journal Article
- Keywords:
Nicorandil;
Atorvastatin;
Unstable angina
- From:
China Pharmacy
2021;32(11):1370-1375
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE：To systematically evaluate the effectiveness and safety of nicorandil combined with atorvastatin calcium in the treatment of unstable angina pectoris ，and to provide reference for clinical treatment. METHODS ：Retrieved from PubMed，Cochrane Library ，Embase database ，CBM，VIP，CNKI and Wanfang database ，randomized controlled trials （RCTs） about nicodil combined with atorvastatin calcium in the treatment of unstable angina pectoris were collected from the inception until Jan. 3rd，2021. The included studies were screened and evaluated with modified Jadad scale. Meta-analysis was performed by using Rev Man 5.3 software. RESULTS ：A total of 10 RCTs were included ，involving 1 123 patients. Meta-analysis results showed that compared with atorvastatin calcium group ，nitcodil combined with atorvastatin calcium group significantly increased angina response rate [OR ＝3.44，95％CI（2.35，5.04），P＜0.001]，the rate of electrocardiogram improvement [OR ＝4.93，95％CI（2.88， 8.43），P＜0.001]，and significantly reduced MMP- 9 level [SMD ＝－4.21，95％CI（－4.63，－3.80），P＜0.001]，incidence of recurrent angina pectoris [OR ＝0.30，95％CI（0.12，0.71），P＝0.006]，myocardial infarction rate [OR ＝0.27，95％CI（0.08，0.89）， P＝0.03]，the incidence of adverse cardiovascular events [OR ＝0.34，95％ CI（0.21，0.55），P＜0.001]. CONCLUSIONS ： Nicorandil combined with atorvastatin calcium shows better efficacy in the treatment of unstable angina pectoris in terms of effective rate of angina pectoris ，improvement rate of cardiogram ，MMP-9 level，incidence of recurrent angina pectoris and the incidence of myocardial infarction ，and has better safety in the incidence of adverse cardiovascular events. Due to the limitation of included studies ，it remains to be verified by RCT with large sample，multi-center and high quality.
