Effect of inhaled budesonide on the prevention of bronchopulmonary dysplasia in premature infants and its impact on the development of intelligence at 1 year old
10.3969/j.issn.1006-2483.2021.02.018
- VernacularTitle:布地奈德化吸入对早产儿支气管肺发育不良及1岁时智能发育的影响
- Author:
Qian XYU
1
;
Shunxian ZHANG
2
;
Lirong LUO
1
;
Hongli WANG
1
;
Minhong XU
1
;
Shaowei YU
1
Author Information
1. Department of Pediatrics, Guangzhou Red Cross Hospital Affiliated to Medical College of Jinan University , Guangzhou 510523,China
2. Guangzhou Women's and Children's Medical Center，Guangzhou 510523，China
- Publication Type:Journal Article
- Keywords:
Bronchopulmonary dysplasia;
Inhaled budesonide;
Prevention;
Neural development
- From:
Journal of Public Health and Preventive Medicine
2021;32(2):77-80
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate potential protective effects of inhaled budesonide on bronchopulmonary dysplasia (BPD) in premature infants and its impact on the intelligence development at 1 year of age. Methods A total of 82 preterm infants admitted to the neonatal intensive care center from January 2017 to January 2018 were selected as research subjects. The enrolled subjects were divided into a study group (Budesonide) and a control group (saline) by random number table method, with 41 cases in each group. The incidence of BPD, mortality, hospitalization time, time of withdrawal and oxygenation, and complications were compared between the two groups. The patients were regularly followed up to 1 year old after discharge. The physical growth and Gesell intelligence development of the two groups were compared. Results The incidence of BPD in the study group was significantly lower than that in the control group, and the difference was statistically significant (P<0.05). There was no significant difference in mortality between the two groups. The hospitalization time, weaning and oxygenation time, and 1-week re-intubation rate in the study group were significantly lower than those in the control group (P<0.05). There was no significant difference between the two groups in the incidence of adverse reactions and physical growth at 1 year old and Gesell intelligence evaluation. Conclusion Budesonide aerosol inhalation reduced the incidence of BPD in premature infants, shortened hospitalization and weaning time, and there were no near-term and long-term adverse reactions.
