Hedgehog signalling molecule, SMO is a poor prognostic marker in bladder cancer
- Author:
Khairunnisa Mohd Ariffin
1
Author Information
1. Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
- Collective Name:Fauzah Abd Ghani; Huzlinda Hussin; Salmiah Md. Said; Rosna Yunus; Abhimanyu Veerakumarasivam; Maizaton Atmadini Abdullah
- Publication Type:Journal Article
- Keywords:
Hedgehog pathway;
SMO;
immunohistochemistry;
bladder cancer
- From:The Malaysian Journal of Pathology
2021;43(1):49-54
- CountryMalaysia
- Language:English
-
Abstract:
Introduction: Hedgehog (HH) pathway is an important signalling cascade for growth and patterning
during embryonic development. Constitutive activation of Hedgehog pathway can be found in
various types of malignancies including medulloblastoma, basal cell carcinoma, gastrointestinal,
breast, pancreatic, prostate cancer and leukaemia. Little is known about the expression and role of
Hedgehog signalling in bladder cancer. Materials and Methods: The purpose of this study was to
investigate the immunohistochemical expression of SMO in 112 bladder cancer cases and determine
their association with demographic and clinicopathological parameters. Bladder cancer tissues were
obtained from the Hospital Kuala Lumpur. Results: SMO was expressed in the cytoplasm of all
cases of bladder cancer. 6 cases (5.4%) showed low expression, while 106 cases (94.6%) showed
high expression. Positive expression of SMO protein was correlated with a few variables which
include grade and stage of tumour, lymph node metastasis and distant metastasis. SMO expression
showed statistically significant association with higher grade (p=0.001) and higher stage (p=0.042)
of bladder cancer. SMO expression also showed borderline association with lymph node metastasis
(p=0.056). Conclusion: These findings indicate that SMO expression may be a poor prognostic
marker in bladder cancer.
- Full text:5.2021my01108.pdf
