Research progress on the Hippo-YAP signaling pathway mediated osteoimmunology in modulating implant osseointegration
- Author:
ZHOU Anqi
1
;
LIU Jiayi
1
;
JIA Yinan
1
;
XIANG Lin
2
Author Information
- Publication Type:Review
- Keywords: osseointegration; bone repair; Hippo-YAP signaling pathway; osteoimmunology; implants; osteogenesis; bone remodeling; macrophages
- From: Journal of Prevention and Treatment for Stomatological Diseases 2021;29(5):334-339
- CountryChina
- Language:Chinese
- Abstract: Ideal osseointegration is intimately related to favorable osteoimmune properties around dental implants. An increasing number of in vitro and in vivo studies have indicated that the Hippo-YAP signaling pathway is involved in this biological process. In this article, the implicated roles of Hippo-YAP the signaling axis in peri-implant osteoimmunology were summarized by reviewing relevant evolving literature. The discrepancy concerning the Hippo-YAP signaling regulatory effect on osteogenesis and polarization direction were analyzed as well as propose the potential mechanism, which may be caused by the maturation of osteogenesis-related cells and heterogeneity of macrophages. More attention should be given to the requirements of promoting osteogenesis and patterns of regulating the immune microenvironment by Hippo-YAP in future studies.
- Full text:Hippo-YAP信号轴介导骨免疫调节种植体骨结合的研究进展.pdf
