Mechanism of action of estrogen and its receptor in the development and progression of nonalcoholic fatty liver disease
DOI:10.3969/j.issn.1001-5256.2021.02.046
- VernacularTitle:雌激素及其受体在非酒精性脂肪性肝病发生发展中的作用机制
- Author:
Juan PENG
1
;
Liangping LI
Author Information
1. Department of Gastroenterology, Chuanbei Medical College, Nanchong, Sichuan 637000, China
- Publication Type:Research Article
- Keywords:
Non-alcoholic Fatty Liver Disease;
Estrogens;
Receptors, Estrogen
- From:
Journal of Clinical Hepatology
2021;37(2):467-470
- CountryChina
- Language:Chinese
-
Abstract:
The incidence rate of nonalcoholic fatty liver disease (NAFLD) has increased sharply, and there is still a lack of effective pharmacotherapy at present. Although great achievements have been made in the research on the pathogenesis of NAFLD, we still do not know enough about the gender differences of NAFLD. As an important sex hormone, estrogen affects the development and progression of NAFLD by regulating mood and energy homeostasis, adipose tissue function and distribution, inflammatory response, insulin resistance, liver fat accumulation, and liver immunity. An adequate understanding of the mechanism of action of estrogen and its receptor in NAFLD may provide new ideas for the treatment of NAFLD.
