Review of Chemical Constituents, Pharmacological Effects and Clinical Applications of Taohong Siwutang and Predictive Analysis of Its Quality Marker
10.13422/j.cnki.syfjx.20191953
- VernacularTitle:桃红四物汤化学成分、药理作用、临床应用的研究进展及质量标志物的预测分析
- Author:
Xin NIE
1
;
Yan-fen CHENG
1
;
Lin WANG
1
;
Chao-mei FU
1
;
Yao HE
1
;
Jin-ming ZHANG
1
Author Information
1. College Pharmacy, Chengdu University of Traditional Chinese Medicine, Key Laboratory of Standardization of Chinese Herbal Medicine, Ministry of Education, Key Laboratory of Systematic Research, Development and Utilization of Chinese Medicine Resources in Sichuan Province, Key Laboratory Breeding Base of Co-founded by Sichuan Province and Ministry of Science and Technology, Chengdu 611137, China
- Publication Type:Research Article
- Keywords:
Taohong Siwutang;
quality marker (Q-marker);
classical famous formulas;
quality control;
chemical constituents;
pharmacological activities;
clinical application
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2020;26(4):226-234
- CountryChina
- Language:Chinese
-
Abstract:
Taohong Siwutang is a classical famous formula for promoting blood circulation and removing blood stasis. This paper reviewed the research progress of chemical constituents, pharmacological activities, clinical applications of Taohong Siwutang in recent years. At present, the study on the chemical constituents of different extracts of Taohong Siwutang is systematic. The study of its pharmacological effects mostly includes promoting blood circulation and removing blood stasis, regulating menstruation, promoting fracture healing, and so on. In clinical practice, Taohong Siwutang can be used in the treatment of multi-system and multi-viscera diseases, such as gynecological diseases, internal diseases, orthopedic diseases, dermatological diseases, and the like. Based on this, the quality markers of Taohong Siwutang are predicted and analyzed from the perspectives of quality transmissibility and traceability, ingredient specificity, component validity, component measurability, and formula compatibility environment, which is called five principles of quality marker (Q-marker). According to the analysis, ferulic acid, paeoniflorin, amygdalin, albiflorin, hydroxysafflor yellow A, catalpol and gallic acid can be selected as Q-markers of Taohong Siwutang. Subsequently, these Q-markers can be selected as indicators to conduct whole quality control of Taohong Siwutang and establish a quality traceable system by the quality transmitting of medicinal materials, decoction pieces, intermediates and corresponding objects, so as to provide a reference for the study of the whole process quality control system of Taohong Siwutang.
