Investigating Clinical Efficacy and Mechanism of Qingfei Paidu Decoction for Treatment of COVID-19 Based on Integrative Pharmacology
10.13422/j.cnki.syfjx.20201638
- VernacularTitle:基于整合药理学探讨清肺排毒汤治疗新型冠状病毒肺炎的功效及作用机制
- Author:
Xiu-juan PENG
1
;
Xin-jie YANG
2
;
Gang XU
3
;
Yan-bin CHEN
3
;
Chang-hua YANG
1
;
Wei-ling GONG
1
;
Dong HAN
1
;
Feng LIU
1
Author Information
1. Shaanxi Institute of International Trade & Commerce，Xi'an 712046，China
2. Shaanxi University of Chinese Medicine，Xi'an 712046，China
3. Shaanxi Buchang Pharmaceutical Co.Ltd.，Xi'an 710075，China
- Publication Type:Research Article
- Keywords:
coronavirus disease-2019（COVID-19）;
Qingfei Paidu decoction;
clinical efficacy;
mechanism;
integrative pharmacology
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2020;26(16):6-13
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Potential targets and pathways of Qingfei Paidu decoction（QFPD）for treating coronavirus disease-2019（COVID-19） were analyzed based on the integrative pharmacology，the efficacy and material basis was predicted.This study provide a reference for the development and clinical application of QFPD. Method:Based on the integrative pharmacology of traditional Chinese medicine（TCMIP V2.0），the key targets and pathways of the intervention of QFPD on COVID-19 were enriched，the interaction network of "formula-herb-disease-targets-pathways" was constructed to explored the molecular mechanism of QFPD for the treatment of COVID-19. Result:The research results show that key-targets such as cell tumor antigen p53（tp53），protein kinase B1（Akt1），Nuclear factor nuclear transcription factor-κB（NF-κB）p105 subunit（NFKB1），nuclear factor p65 subunit（RELA），human NF-κB inhibited protein α（NFKBIA），ect.Closely associated with lung damage.The pathways such as interleukin signaling，adrenoceptors，7 members of the family of c-type lectin domains A（CLEC7A）/inflammasome pathway，phosphoinositide-3-kinase（PI3K）/protein kinase B（Akt）inflammatory signaling pathway，tp53 regulates transcription of DNA repair ect. may be the key pathways related with QFPD's effect on the treatment of COVID-19 accompany with lung injury， fever， cough and other symptoms.The results show that QFPD has many clinical effects， such as anti-inflammatory， anti-virus， strengthening immunity， inhibit the development of pulmonary fibrosis， protecting heart and lungs， treating asthma， regulating gastrointestinal tract， etc.In addition， there is a good synergism between the original prescription and the combined prescription， and each original prescription has its own emphasiscan prevention and treatment of COVID-19. Conclusion:QFPD plays a role in balancing immunity and eliminating inflammation，and it can treat COVID-19 by multi-pathway，multi-channel，multi-target and multi-link.This study also provides a new idea for the research of prevention and treatment of modern infectious diseases by use the traditional Chinese medicine.
