Discussion on Pathogenesis and Treatment of Type 2 Diabetes from Perspective of Intestinal Microecology
10.13422/j.cnki.syfjx.20201538
- VernacularTitle:从肠道微生态角度探讨2型糖尿病的发病机制以及治疗措施
- Author:
Yun HE
1
;
Li-xia YANG
2
;
Lian-li QIU
3
Author Information
1. Gansu University of Chinese Medicine，Lanzhou 730000，China
2. Gansu Province Academy of Traditional Chinese Medicine（TCM），Lanzhou 730020， China
3. Gansu Provincial Hospital of TCM，Lanzhou 730699，China
- Publication Type:Research Article
- Keywords:
intestinal flora;
intestinal flora imbalance;
type 2 diabetes（T2DM）;
T2DM treatment
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2020;26(15):229-234
- CountryChina
- Language:Chinese
-
Abstract:
Diabetes is a kind of disease which poses a great threat to human health. Its occurrence and development are often related to many factors such as heredity and environment. According to the eighth edition of Diabetes Federation's diabetes map in 2017， there are about 425 million diabetics in the world. It is estimated that by 2045， the number of diabetics will increase to 700 million， becoming a health problem that has attracted increasing attention all over the world， among which the number of type 2 diabetics （T2DM）accounts for more than 90% of the total. Therefore， it is of great significance to study the pathological mechanism for the effective prevention and treatment of diabetes. Intestinal microflora coexists with human beings and forms an important micro ecosystem， which is involved in the metabolism of substance and energy. In recent years， with the development of high-throughput sequencing technology， a large number of studies have shown that in addition to obesity， genetic and insulin dysfunction， intestinal flora disorder may also lead to diabetes. The unbalanced diet structure of T2DM patients destroys the balance of intestinal flora. It is generally believed that the occurrence and development of T2DM may be one of the results of the intestinal microbial disorder caused by over nutrition. However， there is no clear mechanism of how intestinal flora participates in the development of T2DM. At present， it is generally believed that the intestinal flora may affect the metabolism of the body through the participation in bile acid metabolism， short chain fatty acid metabolism， low-level inflammatory response and other ways. At present， the prevention and treatment of T2DM is mainly based on drug control. Through surgical operation， increasing the number of probiotics， fecal transplantation and other methods to intervene the intestinal microflora to adjust the intestinal microflora， it provides a new means for the prevention and treatment of T2DM. This paper discusses the interaction between T2DM and intestinal microflora in recent years and the possible treatment measures in the future.
