Research Progress of Animal Model of Tic Disorder and Its Application in Traditional Chinese Medicine
10.13422/j.cnki.syfjx.202014010
- VernacularTitle:抽动障碍动物模型的研究进展及在中医药研究中的应用
- Author:
Peng FENG
1
;
Zheng-gang SHI
1
;
Huan YANG
1
;
Zhi-qian SUN
1
;
Wen-zhen LUO
1
Author Information
1. Gansu University of Chinese Medicine， Lanzhou 730000， China
- Publication Type:Research Article
- Keywords:
tic disorder;
animal model;
traditional Chinese medicine;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2020;26(15):207-213
- CountryChina
- Language:Chinese
-
Abstract:
Tic disorder （TD） is a neurodevelopmental disorder， with one or more motor and/or vocal disorders as the main symptoms. It brings many inconveniences to children's learning and life， and has a profound impact on children's character building. The pathogenesis of TD is mainly correlated with neurotransmitter release disorder， neuroimmune， genetic， trace element imbalance， diet and other factors， but has not been completely clear up to now. Western Medicine has obvious effects on TD， but with serious side effects. Compared with western medicine， traditional Chinese medicine （TCM） has the advantages of low adverse reactions and definite and lasting effect， and thus has been widely recognized by children and their families. In order to explore the pathogenesis of TD and the specific mechanism of TCM in the treatment of TD， many scholars have carried out a large number of in-depth animal experiments and made some achievements， but also exposed some defects， such as the single modeling method， failed to take into account other pathogenesis of TD， failure to combine the specific syndromes of TCM for targeted modeling， and failure to reflect the dialectic of TCM on the characteristics of governance. This paper reviews the modeling methods of common animal models， the comparison of advantages and disadvantages， and the changes of behavioral and biochemical indicators before and after the intervention with TCM compounds on TD animal models， so as to provide reference for the selection of animal models in future animal experimental research.
