Advances in Research of Cell Pyroptosis, Ulcerative Colitis and Regulation with Traditional Chinese Medicine
10.13422/j.cnki.syfjx.20201501
- VernacularTitle:细胞焦亡与溃疡性结肠炎及中医药调控的研究进展
- Author:
Na WU
1
;
Xiang-kun MAO
2
;
Nan YU
2
;
Hua-shan LI
3
Author Information
1. Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine （TCM）， Nanchang 330006， China
2. Nanchang Hongdu Hospital of TCM， Nanchang 330006， China
3. Guang'anmen Hospital， China Academy of Chinese Medical Sciences， Beijing 100053， China
- Publication Type:Research Article
- Keywords:
pyroptosis;
ulcerative colitis;
Nod-like receptor protein 3（NLRP3）;
traditional Chinese medicine
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2020;26(15):200-206
- CountryChina
- Language:Chinese
-
Abstract:
Pyroptosis，which is different from cell necrosis， apoptosis and autophagy，is a new type of programmed cell death. It is characterized by the swelling of cells until the cell membrane rupture， resulting in the release of cell contents and the activation of a strong inflammatory response. Pyroptosis signaling pathway is divided into the classical pathway dependent on Caspase-1 and the non-classical pathway dependent on Caspase-4， 5 and 11. In classical pathway， activation Caspase-1 depends on inflammasome， whereas in non-classical pathway， Caspase-4， 5， and 11 are activated directly. All of these result in the cleavage of gasdermin D（GSDMD） protein， the formation of membrane pores， the maturation and release of interleukin-1β（IL-1β） and IL-18， and the rupture of the cell membrane， and then leads to pyroptosis. Ulcerative colitis （UC） is a common disease of the digestive system. The UC course is long， easy to relapse， and difficult to cure. The pathogenesis of UC is not completely clear. In recent years， it has been found that pyroptosis plays an important role in the development of UC. Traditional Chinese medicine（TCM） has a long history of preventing and treating UC， with significant clinical effects. It is found that the mechanism of TCM in the prevention and treatment of UC is closely correlated with inflammasome， IL-1β and IL-18. The mechanism of TCM in preventing and treating UC is correlated with cell pyroptosis. Therefore， this paper reviews the relationship between cell pyroptosis and UC and the regulatory effect of TCM.
