Current Research Status of Aptamer-mediated Liposome Targeted Delivery of Antitumor Drugs
10.13422/j.cnki.syfjx.20201554
- VernacularTitle:核酸适配体介导脂质体靶向递送抗肿瘤药物的研究现状
- Author:
Kun ZHU
1
;
Zhong-lan YANG
1
;
Xiao-qing ZHANG
1
;
Shuang-cheng NING
1
;
Li-li ZHOU
1
;
Man-shu ZOU
1
;
Xin-hua XIA
1
Author Information
1. Hunan University of Chinese Medicine,Changsha 410208,China
- Publication Type:Research Article
- Keywords:
aptamer-liposome targeted drug delivery system;
tumor markers;
nucleic acid aptamer technology;
liposomes;
anti-tumor;
systematic evolution of ligands by exponential enrichment technology
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2020;26(20):206-212
- CountryChina
- Language:Chinese
-
Abstract:
Tumor has become the second most serious disease that threatens human health and life. Treating with chemical drugs (referred to as chemotherapy) is the most basic treatment, but most chemotherapeutic drugs cause damage to normal tissues. It is a difficult problem in the field of biomedical research that how to deliver anti-tumor drugs more efficiently, increase the concentration of drugs in tumor tissues, enhance the anti-tumor effect, and decrease the drug distribution in normal tissues to weaken the damage to normal tissues. In order to achieve the goals of accurate delivery of anti-tumor drugs and synergism and attenuation, the researchers used systematic evolution of ligands by exponential enrichment technology (SELEX technology) to screen aptamers that can specifically target tumor markers or tumor cells, and designed the novel liposome targeting drug delivery system with aptamers as targeting molecules (ligands). This paper briefly introduced nucleic acid aptamer technology and common tumor markers, and reviewed the research advances on the antitumor effect of aptamer-liposome drug delivery system. It will provide references for the selection of appropriate tumor markers as targets and the application of aptamer technology in the research and development of high-efficiency and low-toxicity liposome targeting agents of anti-tumor traditional Chinese medicine. Meanwhile, it is of great significance for promoting the application of aptamer technology in targeted drug delivery systems.
