Clinical Observation of Qifu Huazhuo Decoction in Treating Intermittent and Chronic Gout
10.13422/j.cnki.syfjx.20202221
- VernacularTitle:芪茯化浊汤对发作间歇期和慢性期痛风的疗效观察
- Author:
Xuan XIA
1
;
Wen-jie LI
1
;
Lei ZHANG
1
;
Yong-liang CHU
1
Author Information
1. The Second Clinical Medical College，Guangzhou University of Chinese Medicine， Guangzhou 510140，China
- Publication Type:Research Article
- Keywords:
Qifu Huazhuo decoction;
intermittent;
chronic gout
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2020;26(23):120-124
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the efficacy and safety of Qifu Huazhuo decoction in treating intermittent and chronic gout. Method:A total of 160 eligible patients with intermittent and chronic gout were divided into intervention group and control group according to treatment methods， 80 cases in each group. Qifu Huazhuo decoction combined with febuxostat was given in intervention group by oral administration， while the patients in control took febuxostat combined with sodium bicarbonate tablet. After twelve weeks of treatment in both groups， the onset frequency of gout， the degree of joint pain， the levels of uric acid， creatinine， alanine transaminase in the blood， number of cases to use analgesics and adverse events were recorded compared before and after treatment. Twelve weeks follow-up was also conducted after the treatment. Result:The total effective rate was 91.25% （73/80） in intervention group， higher than 83.75% （67/80） in control group， with a significant difference between two groups （χ2=0.16， P<0.05）. Intervention group was superior to control group in improvement of onset frequency of gout， joint pain （P<0.05）， and blood uric acid （P<0.05）. There was no significant difference between two groups in blood creatinine and alanine transaminase. The number of patients using analgesics was less in intervention group （P<0.05）. In terms of adverse reactions， there were two cases of fever， two cases of abnormal liver function， six cases of abnormal kidney function and three cases of gastrointestinal reaction after the treatment in intervention group. While for control group， there were one case of fever， two cases of abnormal liver function， eight cases of abnormal kidney function and five cases of gastrointestinal reaction， without significant differences between two groups. Conclusion:The Qifu Huazhuo decoction can effectively reduce the onset frequency of gout and the degree of joint pain in intermittent and chronic phases， effectively control the level of blood uric acid， and reduce the number of cases using analgesics， with less adverse reactions， so it is suitable for clinical use.
