Research Progress of ZHANG Zhong-jing's Classical Formulae in Treatment of Depression
10.13422/j.cnki.syfjx.20202337
- VernacularTitle:仲景方药辨治抑郁症研究进展
- Author:
Yao-yang LI
1
;
Li-zhi SHANG
2
;
Er-ping XU
2
Author Information
1. The First Clinical School of Henan University of Chinese Medicine， Zhengzhou 450006，China
2. Henan Key Laboratory for Modern Research of Zhongjing Compound Traditional Chinese Medicine，Zhengzhou 450046，China
- Publication Type:Research Article
- Keywords:
ZHANG Zhong-jing's classical formulae;
depression;
research progress;
Bupleuri Radix class prescription;
Gardeniae Fructus class prescription
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2020;26(23):1-11
- CountryChina
- Language:Chinese
-
Abstract:
Depression is a kind of emotional and mental disorder， which is related to many pathogenic factors， such as abnormal metabolism of monoamine neurotransmitters， immune inflammatory reaction， neuroendocrine disorder and so on. it has the characteristics of high disability rate and high recurrence rate， which is seriously harmful to human health. It brings huge economic burden to patients and their families. At present， the commonly used antidepressants in clinic are monoamine oxidase inhibitors， tricyclic antidepressants and selective 5-hydroxytryptamine reuptake inhibitors. Long-term use causes adverse reactions such as cardiovascular， urinary and digestive dysfunction. The multi-target， multi-pathway and multi-mechanism of traditional Chinese medicine has played a great role in the treatment and rehabilitation of depression. At the same time， traditional Chinese medicine has gradually become a hot spot in the research and development of antidepressants because of its small side effects and good drug compliance. Especially the ZHANG Zhong-jing's classical formulae with precise medication and rigorous prescription has unique advantages in the treatment of depression. For thousands of years， it has been used clinically by countless doctors in the treatment of various types of depression， with definite curative effects and few side effects. In recent years， clinical research， experimental research， and pharmacological research around ZHANG Zhong-jing's classical formulae for depression have been continuously expanded and deepened. This article reveals the rules of medication of the treatment of depression with ZHANG Zhong-jing's classical formulae from three aspects of Bupleurum class prescription， Gardenia class prescription， and other prescriptions， which is reflected in the study on the composition of prescription， the etiology， and pathogenesis and the symptoms of the treatment. Integrating and classifying ZHANG Zhong-jing's classical formulae's experience in the treatment of depression， mainly expounded from two aspects， clinical research and pharmacological research， summarizing the research perspective and progress of Zhongjing prescription medicine in the treatment of depression in recent years， to excavate， inherit and develop ZHANG Zhong-jing's classical formulae， and provide experience and reference for the treatment of depression from multiple angles and ideas.
