Discussion on Prescription Discovery and Molecular Mechanism of Portulacae Herba in Treating Diabetes Mellitus Based on Data Mining and Integrative Pharmacology
10.13422/j.cnki.syfjx.20201552
- VernacularTitle:基于数据挖掘和整合药理学的马齿苋治疗糖尿病的处方发现及分子机制探讨
- Author:
Jin-li HOU
1
;
Ping WANG
2
;
Yan-qiong ZHANG
2
;
Shi-huan TANG
2
;
Feng LIU
3
;
Li-ping YU
4
;
Hai-yu XU
2
Author Information
1. School of Chinese Materia Medica，Yunnan University of Chinese Medicine，Kunming 650500，China
2. Institute of Chinese Materia Medica，China Academy of Chinese Medical Sciences，Beijing 100700，China
3. Shaanxi Institute of International Trade & Commerce，Xianyang 712046，China
4. Guangzhou Zhongda Pharmaceutical Development Co. Ltd.，Guangzhou 510000，China
- Publication Type:Research Article
- Keywords:
Portulacae Herba;
Traditional Chinese Medicine Inheritance Support System （TCMISS）;
Encyclopedia of TCM （ETCM）;
integrative pharmacology;
formula;
protein kinase;
molecular mechanism
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2020;26(24):1-10
- CountryChina
- Language:Chinese
-
Abstract:
Objective:A new prescription containing Portulacae Herba was created and the molecular mechanism of the new prescription for treating diabetes was clarified based on big data of traditional Chinese medicine （TCM）. Method:Taking Portulacae Herba as the key word， the TCM Inheritance Support System and Encyclopedia of TCM （ETCM） were used to excavate the most frequently used medicines combined with Portulacae Herba， and form a new prescription. Based on the basic theory of TCM， this paper analyzed the rationality of the new prescription in treating diabetes， and used the Integrative Pharmacology-based Research Platform of TCM （TCMIP） to predict the target of the new prescription， and constructed the interaction network between drugs and targets of diabetes-related diseases， the key targets of drug intervention were enriched and analyzed， and the network graph of TCM-chemical composition-key target-pathway was drawn. Result:There were 89 prescriptions containing Portulacae Herba in ETCM. The most frequently used medicines in combination with Portulacae Herba were Phellodendri Chinensis Cortex， Rehmanniae Radix and Saposhnikoviae Radix， the four medicines were combined into a new prescription. According to the new prescription to treat diabetes， 89 key core target information was obtained， among which there were 10 targets of drug and disease， including phosphoinositide-3 kinase regulatory subunit 1 （PIK3R1）， insulin （INS）， glucokinase （GCK）， etc. The new prescription treated diabetes by regulating growth hormone receptor signaling， protein kinase A （PKA） activation， adrenoceptors and other pathways. Conclusion:The therapeutic effect of new prescription containing Portulacae Herba created by big data analysis of TCM on diabetes reflects multi-component， multi-target， multi-pathway characteristics of TCM， which can provide scientific basis for explaining the mechanism and material basis of this new prescription in the treatment of diabetes.
