Chemical constituents of triterpenoid saponins from Glycyrrhiza glabra
10.16438/j.0513-4870.2020-1406
- VernacularTitle:光果甘草三萜皂苷类化学成分研究
- Author:
Yun-feng ZHENG
1
;
Jie SUN
2
;
Wei-ping DUAN
2
;
Yang LI
2
;
Li-hong CHEN
2
;
Tu-lin LU
2
;
Cun-yu LI
1
;
Gou-ping PENG
1
Author Information
1. School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China; Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing 210023, China
2. School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
- Publication Type:Research Article
- Keywords:
italic>Glycyrrhiza glabra L.;
chemical composition;
triterpenoid saponin
- From:
Acta Pharmaceutica Sinica
2021;56(1):289-295
- CountryChina
- Language:Chinese
-
Abstract:
Ten triterpenoid saponins were isolated and purified from the water extract of Glycyrrhiza glabra by polyamide resin combined with macroporous resin column chromatography, ODS medium pressure column chromatography and semi-preparative RP-HPLC. Their structures were elucidated by physicochemical properties, NMR and MS spectra, and determined as 3β-O-[β-D-glucuronpyranosyl-(1→2)-β-D-glucuronpyranosyl]-30β-O-β-D-glucuronpyranosyl-oleanane-11-oxo-12(13)-ene (1), 3β-O-[β-D-glucuronpyranosyl-(1→2)-β-D-glucuronpyranosyl]-30β-O-α-L-rhamnopyranosyl-oleanane-11-oxo-12(13)-en-22β,30-diol (2), uralsaponin C (3), licorice-saponin A3 (4), licorice-saponin P2 (5), 22β-acetoxyl-glycyrrhizin (6), macedonoside A (7), 29-hydroxyl-glycyrrhizin (8), licorice-saponin G2 (9), glycyrrhizin (10). Compounds 1 and 2 are two new compounds and named as licorice-saponin R3 and licorice-saponin S3.
