Placental immune cells and gestational diabetes mellitus
10.3760/cma.j.cn113903-20190915-00558
- VernacularTitle:胎盘免疫细胞与妊娠期糖尿病
- Author:
Jiayuan CHEN
1
;
Haidong CHENG
;
Qingying ZHANG
;
Yan CHENG
Author Information
1. 复旦大学附属妇产科医院产科，上海 200090
- From:
Chinese Journal of Perinatal Medicine
2020;23(7):496-501
- CountryChina
- Language:Chinese
-
Abstract:
Placenta, the direct and vital connection between mother and fetus, can be considered as an inflammatory organ that plays an essential role in maternal-fetal immune tolerance in maintaining pregnancy and mediating inflammation in some gestational complications. When gestational diabetes mellitus (GDM) occurs, the mother and placenta are in a state of mild inflammation. We hypothesize that the placental immune cells may participate in the pathogenesis of GDM. This review discusses the relation between placental immune cells and GDM from three aspects: the regulatory function of the placental immune cells, the association between abnormal placental immune cells and GDM, and the function of placental immune cells during clinical management of GDM.
