Anti-contactin-1 IgG4 antibody associated chronic inflammatory demyelinating polyradiculoneuropathy: a case report
10.3760/cma.j.cn113694-20200504-00324
- VernacularTitle:抗接触蛋白1抗体相关慢性炎性脱髓鞘性多发性神经根神经病一例
- Author:
Ju ZHU
1
;
Yang LIU
;
Li TIAN
;
Na LIU
;
Zhecheng ZHANG
Author Information
1. 天津市第三中心医院神经内科 300170
- From:
Chinese Journal of Neurology
2020;53(12):1044-1048
- CountryChina
- Language:Chinese
-
Abstract:
Anti-contactin-1(CNTN1) IgG4 antibody is a reliable biomarker of a specific subset of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) patients with distinct clinical features, including advanced age, aggressive symptom, predominantly motor involvement, sensory ataxia, and poor response to intravenous immunoglobulin. Nerve conduction study showed decrease of nerve conduction velocity, reduction of compound motor active potential amplitude without temporal dispersion at early stage of the disease. The article reported an anti-CNTN1 IgG4 antibody positive case, reviewed the current relevant literature, and then summarized the clinical characteristics of anti-CNTN1 IgG4 antibody associated CIDP.
