Research progress in epigenetic studies of focal cortical dysplasia
10.3760/cma.j.cn113694-20200113-00038
- VernacularTitle:局灶性皮质发育不良的表观遗传学研究进展
- Author:
Juan LIN
1
;
Yueshan PIAO
Author Information
1. 首都医科大学宣武医院病理科，北京 100053
- From:
Chinese Journal of Neurology
2020;53(8):623-626
- CountryChina
- Language:Chinese
-
Abstract:
Belonging to the mlformations of cortical development category, focal cortical dysplasia (FCD) is a kind of desease caused by abnormal proliferation or abnormal migration of neurons in early embryo development. Epigenetics refers to changes in gene expression without changes in the nucleotide sequence of a gene, and these changes are heritable. It regulates gene expression mainly through DNA methylation, histone modification, chromatin remodeling and non-coding RNA.It is now considered that the epigenetic mechanism may be closely related to the pathogenesis of FCD, which has become a hotspot of FCD research.This paper will review the advances in epigenetic studies of FCD.
