The role of organophosphorus compounds in the pathogenesis of Alzheimer′s disease
10.3760/cma.j.cn113694-20191005-00613
- VernacularTitle:有机磷化合物在阿尔茨海默病发病中的作用研究进展
- Author:
Ting YU
1
;
Zhentao ZHANG
Author Information
1. 武汉大学人民医院神经内科 430060
- From:
Chinese Journal of Neurology
2020;53(5):381-384
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer′s disease is the most common neurodegenerative disease, which is characterized by the formation of neurofibrillary tangles and amyloid plaques in the brain, and the progressive loss of neurons. Epidemiological studies found that exposure to organophosphorus compounds increases the incidence of Alzheimer′s disease. Organophosphorus compounds accelerate the onset of Alzheimer′s disease pathology by inhibiting enzyme activity, promoting oxidative stress, and affecting axonal transport and nerve growth factor pathway. As a result, they cause cognitive dysfunction. Here we reviewed the current knowledge on the role of organophosphorus compounds in the pathogenesis of Alzheimer′s disease, in order to enhance our understanding of the environmental risk factors that contribute to the pathogenesis of Alzheimer′s disease, and to search for potential therapeutic targets for this disease.
