Encephalitis with positive LGI1 antibody: a clinical analysis of 4 cases
10.3760/cma.j.cn114798-20190924-00724
- VernacularTitle:富亮氨酸胶质瘤失活1蛋白抗体阳性脑炎四例临床分析
- Author:
Junhua GAO
1
;
Bowen ZHENG
;
Wurong LI
;
Yuming HUANG
;
Wenqing WU
Author Information
1. 首都医科大学附属北京地坛医院神经内科 100015
- From:
Chinese Journal of General Practitioners
2020;19(4):352-355
- CountryChina
- Language:Chinese
-
Abstract:
The clinical manifestations,serum and cerebrospinal fluid (CSF) results,EEG and imaging findings of 4 cases of encephalitis with positive leucine-rich glioma inactivated protein 1 (LGI1)antibody admited from March 2017 to January 2019 were retrospectively analyzed.All 4 patients were males with a mean age of (42±17) years.Two patients had faciobrachial dystonic seizure(FBDS)as the main symptom,and 3 patients had epilepsy.There were normal blood sodium and no memory deficits in all 4 patients.The LGI1 antibody was positive in the serum and negative in the CSE.The longest diagnosis time was 5 months.The head MRIs were normal in 3 patients;and abnormal signals in the right basal ganglia were found in one case,and the lesicl became smaller after the treatment.Chest CT,abdominal CT,and pelvic CT did not detect tumors.All patients were treated with gamma globulin and glucocorticoids,they all had good prognosis.LGI1 antibody-positive encephalitis is mainly characterized by epilepsy. ldentifying FBDS would be helpful for early diagnosis.Timely treatments often result in good clinical prognosis.
