Effects of cold ischemia time and donor age on postoperative and mid-term follow-ups of heart transplantation
10.3760/cma.j.cn421203-20190912-00348
- VernacularTitle:冷缺血时间及供者年龄对心脏移植院内效果及远期预后的影响
- Author:
Qi LI
1
;
Yunhu SONG
;
Jie HUANG
;
Zhongkai LIAO
;
Juan DU
;
Zhe ZHENG
;
Sheng LIU
Author Information
1. 中国医学科学院阜外心血管病医院心脏外科，北京 100037
- From:
Chinese Journal of Organ Transplantation
2020;41(4):242-246
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effects of cold ischemia time (CIT) and donor age upon postoperative and long-term follow-ups of heart transplantation.Methods:A total of 761 patients underwent orthotopic heart transplantation from 2004 to 2018. According to the length of CIT, they were divided into group of >4 hours (n=502) and group of <4 hours (n=259). Each group was further divided into two subgroups according to the age of donors: group of <40 years and group of <40 years. The basic profiles of recipients and donors were recorded, including applying mechanical assistance during and after operation, postoperative mortality and follow-up survival rate.Results:The average age of donors was (31.1±8.6)(5-58) years and the average CIT (5.3±2.0)(1.0-12.0) hours. No significant difference existed in hospital mortality between CIT groups (3.5% vs 5.6%, P=0.22). In subgroup analysis, there was a significant increase (4.3% vs 12.0%, P=0.01) in subgroup with CIT >4 hours and higher donor age. No significant difference existed in the number of patients using mechanical assistance during or after operation. During follow-ups, no significant difference existed in survival rate between CIT groups ( P=0.97) or survival rate among subgroups. Conclusions:Long CIT has a more significant effect on postoperative mortality of heart donors. However, it does not significantly increase the proportion of mechanical assistance, follow-up mortality and the incidence of cardiac allograft vasculopathy.
