An FT 3/FT 4 ratio greater than 0.4 is helpful in differentiating Graves′ disease from subacute thyroiditis
10.3760/cma.j.cn311282-20191029-00456
- VernacularTitle:FT 3/FT 4比值大于0.4有助于鉴别Graves病和亚急性甲状腺炎
- Author:
Wei WANG
1
;
Ranran WANG
;
Yue LIANG
;
Pingping DANG
;
Defa ZHAO
;
Weiwei XIAO
;
Dan ZHANG
;
Weiping TENG
;
Xiaochun TENG
Author Information
1. 中国医科大学附属第一医院内分泌与代谢病科，内分泌研究所，沈阳 110001
- From:
Chinese Journal of Endocrinology and Metabolism
2020;36(9):794-798
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To search for the clinical indicators in differentiating Graves′ disease from subacute thyroiditis (SAT).Methods:Retrospective analysis was performed on thyroid function measurement of 265 cases of newly diagnosed Graves′ disease, 76 cases of SAT with thyrotoxicosis, 100 cases of non-toxic thyroid nodules, 105 cases of autoimmune thyroid diseases with normal thyroid function, and 151 cases of outpatients with normal thyroid function and without thyroid diseases.Results:Free triiodothyronine(FT 3)/free thyroxine(FT 4) ratio of Graves′ disease patients was significantly higher than that of SAT patients with thyrotoxicosis (0.65±0.29 vs 0.32±0.75, P<0.05). Receiver operating characteristic curve(ROC curve) analysis of FT 3/FT 4 ratio between Graves′ disease group and SAT group showed that FT 3/FT 4 ratio greater than 0.4 with a sensitivity of 98.11% and a specificity of 83.81% for diagnosis of Graves′ disease. Conclusion:FT 3/FT 4 ratio greater than 0.4 is helpful for differentiating Graves′ disease from subacute thyroiditis with thyrotoxicosis.
