Evaluation of accuracy of target-controlled infusion of sufentanil at low concentration during combined intravenous and inhalational general anesthesia
10.3760/cma.j.cn131073.20200402.00819
- VernacularTitle:静吸复合全麻时靶控输注低浓度舒芬太尼的准确性评价
- Author:
Yan ZHAO
1
;
Yujie WANG
;
Weiji QIU
;
Xin XIONG
Author Information
1. 同济大学附属上海市第四人民医院麻醉与围术期医学科 200081(原在北京大学第三医院麻醉科工作)
- From:
Chinese Journal of Anesthesiology
2020;40(8):970-973
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the accuracy of target-controlled infusion (TCI) of sufentanil at low concentration during combined intravenous and inhalational general anesthesia.Methods:Thirty American Society of Anesthesiologists physical status Ⅰ or Ⅱ patients, aged 18-68 yr, with body mass index <35 kg/m 2, scheduled for elective laparoscopic surgery under combined intravenous and inhalational general anesthesia, were selected in the study.Anesthesia was induced with sufentanil TCI, propofol and rocuronium and maintained with sufentanil TCI combined with inhalation of sevoflurane.The patients were divided into 2 groups ( n=15 each) using the computer-generated sequence of random numbers method: 0.10 ng/ml group (groupⅠ) and 0.15 ng/ml group (groupⅡ). Arterial blood samples were collected from the radial artery for determination of plasma sufentanil concentrations by liquid chromatography-mass spectrometry/mass spectrometry.The bias, precision and wobble were calculated. Results:In Ⅰ and Ⅱ groups, the bias of sufentanil TCI was 17.0% and -3.0%, respectively, the precision was 22.4% and 20.3%, respectively, and the wobble was 23.0% and 21.7%, respectively.The pooled bias, precision and wobble were 6.0%, 22.0% and 22.0%, respectively.Conclusion:The accuracy of TCI of sufentanil at low concentration during combined intravenous and inhalational general anesthesia is within the clinically acceptable range, and the measured blood concentration of sufentanil is about 6% higher than the target concentration.
