Research progress on the prevention and treatment of radiation-induced intestinal injury by the genus Lactobacillus
10.3760/cma.j.cn113030-20191108-00013
- VernacularTitle:乳杆菌属防治急性放射性肠损伤的研究进展
- Author:
Tianshu ZHAO
1
;
Yongqiang YANG
;
Shang CAI
;
Ye TIAN
Author Information
1. 苏州大学附属第二医院放疗科 苏州大学放射肿瘤治疗学研究所 215004
- From:
Chinese Journal of Radiation Oncology
2020;29(4):313-316
- CountryChina
- Language:Chinese
-
Abstract:
Acute radiation-induced intestinal injury is the common complication in patients following abdominal and pelvic radiotherapy. However, no effective clinical prevention and treatment interventions are available. As the probiotics and symbiotic bacteria, many species of the genus Lactobacillus are normally present in the gastrointestinal tract and beneficial for the intestinal health. Preclinical studies have reported that the genus Lactobacillus can prevent and treat acute radiation-induced intestinal injury by protecting crypt stem cells, maintaining intestinal barrier and exerting the antioxidant effect, etc. Clinical trials have prompted that oral administration of adequate complex probiotics containing Lactobacillus spp.at one week before radiotherapy contributes to preventing radiation-induced diarrhea. In addition, oral intake of the genus Lactobacillus has the tendency to treat radiation-induced diarrhea and mitigate acute radiation proctitis. At present, no relevant adverse events have been reported.
