Research advances in mechanism of gut microbiota changes after traumatic brain injury
10.3760/cma.j.issn.1001-8050.2020.09.014
- VernacularTitle:创伤性脑损伤致肠道菌群改变机制的研究进展
- Author:
Weijian YANG
1
;
Xing WU
;
Jin HU
;
Liangfu ZHOU
Author Information
1. 复旦大学附属华山医院神经外科，上海 200040
- From:
Chinese Journal of Trauma
2020;36(9):847-852
- CountryChina
- Language:Chinese
-
Abstract:
Traumatic brain injury (TBI) is often accompanied by digestive system dysfunction, such as intestinal dysfunction and dysbacteriosis. The activation of neuroendocrine system after TBI is one of the factors leading to gut microbiota changes. A variety of antimicrobial peptides secreted by Paneth cells are the key factors to maintain intestinal flora homeostasis. The dysfunction of Paneth cells after TBI may be responsible for gut microbiota changes. The authors review the mechanism of gut microbiota changes induced by TBI to provide new ideas for clinical treatment of gut microbiota changes caused by TBI.
