Changes of nitric oxide, endothelin-1, homocysteine and C-reactive protein levels in patients with obstructive sleep apnea hypopnea syndrome complicated with hypertension and their relationship with polysomnography monitoring indexes
10.3760/cma.j.cn121361-20200217-00020
- VernacularTitle:阻塞性睡眠呼吸暂停低通气综合征合并高血压患者一氧化氮、内皮素1、同型半胱氨酸及C反应蛋白水平的变化及与多导睡眠仪监测指标的关系
- Author:
Jian TIAN
1
;
Yunqiu LIU
;
Xuan LAN
;
Xiaoxia TANG
;
Liye WANG
Author Information
1. 开滦总医院林西医院呼吸内科，河北省唐山市 063103
- From:
Clinical Medicine of China
2020;36(4):314-318
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the changes of nitric oxide, endothelin-1 (ET-1), homocysteine (Hcy), C-reactive protein (CRP) levels in patients with obstructive sleep apnea hypopnea syndrome (OSAHS) combined with hypertension and the relationship between the changes and polysomnography monitoring indicators.Methods:A retrospective case-control study was conducted to analyze the clinical data of 115 patients with OSAHS complicated with hypertension, 110 patients with simple OSAHS and 136 healthy persons in Kailuan general hospital and Linxi Hospital of Kailuan general hospital from March 2016 to March 2018. The relationship between sleep related indexes and serological indexes was compared among the three groups.Results:In the control group, simple OSAHS group, OSAHS with hypertension group, the apnea hypopnea index (AHI) was (2.4±0.8), (35.7±12.1), (46.8±13.9) times/h, the lowest oxygen saturation(LSaO 2) was (87.1±6.8) %, (77.8±6.5) %, (66.9±5.1) %, and the mean oxygen saturation(MSpO 2) was (92.7±6.9) %, (80.9±6.7) %, (71.4±6.3) %, and the longest apnea time (LAT) was(4.5±0.7), (48.6±11.3), (58.2±10.4) s. The difference between the three groups was statistically significant ( F values were 637.92, 329.49, 322.96, 1 420.03, respectively, all P<0.05). Nitric oxide in control group, simple OSAHS group and OSAHS combined with hypertension group were (72.8±8.8), (53.7±7.4), (42.6±5.9) μmol/L.Endothelin-1 was(31.1±6.5), (45.4±6.7), (56.6±7.8) ng/L.Hcy was (8.7±1.9), (15.9±6.7), (31.4±6.3) μmol/L.CRP was (1.8±0.6), (18.6±4.3), (25.2±6.4) mg/L.The difference between the three groups was statistically significant ( F valves were 517.46, 419.02, 594.40, 982.14, respectively, all P<0.05). Pearson correlation analysis showed that the levels of endothelin 1, Hcy and CRP in OSAHS patients with hypertension were positively correlated with AHI and LAT (r values were 0.525, 0.704, 0.578, 0.434, 0.464 and 0.449, respectively; all P<0.05), and negatively correlated with LSaO 2 and MSpO 2 (r values were-0.477, -0.458, -0.429, -0.517, -0.534 and -0.617, respectively; all P<0.05). Conclusion:In OSAHS patients with hypertension, nitric oxide decreased, ET-1, Hcy, CRP increased, and polysomnography monitoring indicators were closely related to endothelin-1, Hcy, CRP.
