Role of hypoxia-inducible factor in immunometabolism of sepsis
10.3760/cma.j.cn121430-20200226-00238
- VernacularTitle:缺氧诱导因子在脓毒症免疫代谢中的作用
- Author:
Xiao XIAO
1
;
Mao YE
;
Yan XU
;
Chunling JIANG
Author Information
1. 四川大学华西医院麻醉科，成都 610041
- From:
Chinese Critical Care Medicine
2020;32(3):382-384
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis remains a global disease with high morbidity and mortality. The changes of immune cell metabolism are of great significance in the pathophysiology of sepsis. Hypoxia-inducible factor (HIF) is not only a major regulator of hypoxic adaptive response, but also plays an important role in metabolic pathways such as glycolysis and pentose phosphate pathway of immune cells in sepsis. Current studies have found that pattern recognition receptors, transcription factors, certain metabolic byproducts and kinases all have varying degrees of influence on HIF activity or the cell metabolism involved. This review introduces the role and regulatory mechanism of HIF pathway in the metabolic changes of sepsis immune cells, so as to develop new approaches for the diagnosis and treatment of sepsis in the future.
