Advances in the changes of macrophage metabolism and the regulation of immunometabolism during sepsis
10.3760/cma.j.cn121430-20191021-00049
- VernacularTitle:脓毒症时巨噬细胞代谢变化与其代谢调节研究进展
- Author:
Xiao XIAO
1
;
Li ZHOU
;
Yan XU
;
Chunling JIANG
Author Information
1. 四川大学华西医院麻醉科，成都 610041
- From:
Chinese Critical Care Medicine
2020;32(2):249-252
- CountryChina
- Language:Chinese
-
Abstract:
Immunopathogenesis of sepsis is a very complex process involving the innate immune responses mediated by mononuclear macrophages. However, the maintenance and change of macrophage function is closely associated with their immunometabolism. Macrophages take glucose oxidative phosphorylation as the main metabolic pathway under normal physiological conditions, M1 macrophages increase glucose uptake and anaerobic glycolysis, while M2 macrophages increase fatty acid uptake and oxidative phosphorylation efficiency. Recent findings showed that hypoxia-inducible factor-1α, succinate and glutamine were involved in macrophage function and metabolism regulation. Focusing on macrophages function and their immunometabolism changes in the immunopathogenesis of sepsis will make it possible to target immunometabolism as a breakthrough in the future therapy of sepsis.
