Research and treatment progress of acute lymphoblastic leukemia with NOTCH1 gene mutation
10.3760/cma.j.issn.1008-6706.2020.14.030
- VernacularTitle:伴有NOTCH1基因突变的急性淋巴细胞白血病的研究及治疗进展
- Author:
Feifei LIU
1
;
Jianzhen SHEN
Author Information
1. 福建省血液研究所 福建省血液病学重点实验室 福建医科大学附属协和医院血液内科，福州 350001
- From:
Chinese Journal of Primary Medicine and Pharmacy
2020;27(14):1790-1792
- CountryChina
- Language:Chinese
-
Abstract:
T-cell acute lymphonlastic leukemia(T-ALL) is one of the common hematological malignancies in children and adolescents, and it has a rapid progress and high mortality.Since the first activated mutation in NOTCH1 was found in T-ALL with t(7; 9) translocation in 1991.The pathogenesis and clinical treatment of NOTCH1 gene mutation and T-ALL had made some progress at subsequent years.However, there are still some differences in the prognosis of children and adults after using chemotherapy drugs.Therefore, the differences of prognosis of acute lymphoblastic leukemia with NOTCH1 gene mutation in adults and children and the latest treatment progress are reviewed and hope to provide guidance for clinical treatment.
