Effect of Helicobacter pylori Eradication on Functional Dyspepsia.
- Author:
Sung Eun KIM
1
;
Young Soo PARK
;
Nayoung KIM
;
Min Soo KIM
;
Hyun Jin JO
;
Cheol Min SHIN
;
Sang Hyub LEE
;
Jin Hyeok HWANG
;
Jin Wook KIM
;
Sook Hyang JEONG
;
Dong Ho LEE
;
Hyun Chae JUNG
Author Information
1. Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, Korea. nayoungkim49@empas.com
- Publication Type:Original Article
- Keywords:
Eradication;
Functional dyspepsia;
Helicobacter pylori
- MeSH:
Dyspepsia;
Follow-Up Studies;
Gastritis;
Helicobacter;
Helicobacter pylori;
Humans;
Inflammation;
Interleukin-10;
Interleukin-6;
Interleukin-8;
Male;
Multivariate Analysis;
Pepsinogen A;
Polymorphism, Genetic;
Proton Pumps;
Rome
- From:Journal of Neurogastroenterology and Motility
2013;19(2):233-243
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: This study evaluated the effect of Helicobacter pylori eradication on functional dyspepsia (FD), and the relationship between the changes of histological gastritis and FD symptom responses. METHODS: A total of 213 FD patients diagnosed by Rome III criteria were consecutively enrolled. H. pylori tests and gastritis grade by the Sydney system were performed before and 1 year after the proton pump based-eradication therapy for 7 days. Serum levels of pepsinogen, and genetic polymorphisms IL-6, IL-8 and IL-10 were investigated. RESULTS: Total of 91 patients completed the 1 year follow-up. When the response rate of dyspepsia was compared at 1 year between the non-eradicated group (n = 24) and eradicated group (n = 67), each group showed complete response of 62.5% and 62.7%; satisfactory response (> or = 50%) of 0.0% and 19.4%; partial response (< 50%) of 12.5% and 11.9%; and refractory response of 25.0% and 6.0%, respectively (P = 0.015). In addition, the responder group (complete + satisfactory response) at 1 year showed improvement of activity and chronic inflammation in both the antrum and corpus (all P < 0.001). Multivariate analysis showed that H. pylori eradication (OR, 5.81; 95% CI, 1.07-31.59) and symptom improvement at 3 month (OR, 28.90; 95% CI, 5.29-157.82) were associated with the improvement of dyspepsia at 1 year. Among the successfully eradicated FD patients (n = 67), male (P = 0.013) and higher initial BMI (P = 0.016) were associated with the improvement of dyspepsia at 1 year. CONCLUSIONS: H. pylori eradication improved FD symptoms, as well as gastritis at 1 year, suggesting that inflammation mediates FD.
