Progress in research on the effects of high mobility group box 1 in pediatric rheumatic diseases
10.3760/cma.j.cn101070-20190219-00116
- VernacularTitle:高迁移率族蛋白B1在儿童风湿性疾病中的研究进展
- Author:
Xiaoxia RUAN
1
;
Xuemei TANG
Author Information
1. 重庆医科大学附属儿童医院风湿免疫科，儿童发育疾病研究教育部重点实验室，儿童发育重大疾病国家国际科技合作基地，儿童感染免疫重庆市重点实验室，重庆 400014
- From:
Chinese Journal of Applied Clinical Pediatrics
2020;35(5):398-400
- CountryChina
- Language:Chinese
-
Abstract:
High mobility group box 1 is a kind of non-histone protein which expressed in the nucleus of eukaryotic cells.Which can promote inflammatory reaction and participate in the positive feedback loop of the production of cytokines after translocated outside the cells.As a result, it′s closely related to the pathogenesis of various autoimmune and inflammatory diseases.Recent studies have revealed that high mobility group box 1 may serve as a serum marker of Henoch-Sch?nlein purpura nephritis and lupus nephritis, and a predicator of the prognosis of juvenile idiopathic arthritis and intravenous immunoglobulin resistance in Kawasaki disease.
