Clinical significance of changes of inflammatory cytokines level in trauma patients
10.3760/cma.j.issn.1671-0282.2020.10.011
- VernacularTitle:创伤患者炎症因子水平变化的临床意义
- Author:
Dongdong LI
1
;
Zhong-Wei ZHANG
;
Jianyin HUANG
;
Biao ZHU
Author Information
1. 复旦大学上海医学院肿瘤学系-复旦大学附属肿瘤医院麻醉科/重症医学科，上海 200032
- From:
Chinese Journal of Emergency Medicine
2020;29(10):1333-1336
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the clinical significance and underlying mechanism of changes in serum IL - 18 and IL - 1 beta after trauma.Methods:Enzyme-linked immunosorbent assay was used to detect the levels of IL-18 and IL-1β in trauma patients and healthy controls. The differences in serum IL-18 and IL-1β levels were compared between the two groups, and the levels of IL-18 and IL-1β in the traumatic subgroups were further compared.Results:The serum levels of IL-1β and IL-18 of trauma patients were 80±2.0 pg/mL and 27±3.0 pg/mL, respectively, which were significantly higher than those in healthy controls ( P < 0.01). Serum levels of IL-1β and IL-18 showed an upward trend on the 3rd day after trauma. There were also statistically significant differences within the trauma subgroups ( P < 0.01). Conclusions:The serum levels of IL-18 and IL-1β of post-traumatic patients are increased, indicating that NLRP3 inflammasomes are activated in peripheral blood cells in the early stage of trauma, which aggravates the inflammatory response. The AIS-ISS score is positively correlated with the expression levels of IL-18 and IL-1β in serum, indicating that the more severe the injury, the more severe the inflammatory response.
